They also had a 30 percent lower risk of developing cancer in the contralateral (other) breast. Thanks so much for your advice. My cancer was caught early and all I had was radiation. Let me know if you hear any thing of interest:). Hot flushes are a common side effect of this treatment. Having few or no side effects doesn't mean the drug is not effective. Find out how likely side effects of tamoxifen are and side effects to report to your doctor, including common tamoxifen side effects, advice on tamoxifen and … So far I have been off of Tamoxifen for almost a week and I haven't experience anything unnormal. 5 years ago Tamoxifen side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. … Talk with your health care provider about ways to ease these and other side effects. Learn about side effects, warnings, dosage, and more. I'll be finishing up my 5 years at the end of this month. The length of treatment along with side effects can make it tough to complete treatment. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Conclusions: While the majority of women who used tamoxifen for primary prevention of breast cancer were likely to benefit, substantial discontinuation of tamoxifen before five years and use by women at risk of serious side effects may attenuate benefits for breast cancer prevention. Tamoxifen's selective estrogen activation effects can cause some serious side effects, including blood clots, stroke, and endometrial cancer. Dealing with menopausal symptoms related to hormone therapy can be hard. Women who took tamoxifen for 5 years had a 17 percent lower risk of cancer recurrence and a 9 percent lower risk of death from breast cancer than women who took tamoxifen for only 2 years. I have contacted a naturopathic doctor to discuss next steps. I have not had much luck with the oncologist. It seems like you would start to go thru menopause, if you haven't already. Others may worry about tamoxifen’s rare side effects, including blood clots and increased risk of uterine cancer. When you said you spoke with your doctor, did you mean your oncologist or gynecologist? The benefits of tamoxifen outweigh its risks in women already diagnosed with breast cancer. The antiestrogenic activity O 0. I had not gone into menopause when I started Tamoxifen. Hello sweet soul,Words can't express how good it feels to be posting a blog post again! Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. In rare cases, tamoxifen can cause … Diagnosed at age 38, stage III BC w/ Lymphnode involvement. Side Effects of Tamoxifen. Discuss risks and benefits of tamoxifen with women at high risk for breast cancer and women with ductal carcinoma in situ (DCIS) when considering tamoxifen use to reduce the risk of developing breast cancer. Treatment length depends on the features of your cancer diagnosis. It's amazing no data is out there for my age group so I will keep a journal so I can help some else. Like any drug, tamoxifen can cause side effects. So no estrogen = menopause. Asked 15 Jan 2013 by Cheekycarol Updated 23 May 2017 Topics osteoarthritis, pain, back pain, anastrozole, side effect, skin. Tamoxifen discontinuation was operationalized as ever discontinuing tamoxifen for more than 60 days 13,14 during the 5 years after initial tamoxifen prescription. Serious and life-threatening uterine malignancies, stroke, and pulmonary embolism have been associated with tamoxifen use in the risk reduction setting (women with Ductal Carcinoma in Situ (DCIS) and women at high risk for breast cancer). Today we concentrate on the risks of taking Tamoxifen. Thanks Sally. Everyone reacts differently to drugs. Thanks so much for sharing that information - that makes me feel better. 1. Tamoxifen oral tablet is used to treat and help prevent breast cancer. Check with your doctor immediately if any of the following side effects occur while taking tamoxifen: Some side effects of tamoxifen may occur that usually do not need medical attention. The cancer was the focus and my doctor of 4 years retired. :( Other than that, I don't really know! After taking anastrozole for the 5 years, do the side effects reverse or are you stuck with them? Thanks for response. Awe Some!!!!!!!!!!!!!!!!! Not sure if I will get my period back since I am 54. Like any hormonal therapy medicine, tamoxifen can cause side effects, some of them serious. Fifteen years after starting treatment, there could be 6.7 fewer women experiencing a CV event and 3.3 fewer CV deaths for every 100 women age 50 to 59 years who take tamoxifen for 5 years, compared with 2 years of treatment. Last updated on July 15, 2020. "Product Information. Seems it's been much worse since I started the Tamoxifen, especially the past year. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We comply with the HONcode standard for trustworthy health information -, Absent, missed, or irregular menstrual periods, Abnormal growth filled with fluid or semisolid material, clear or bloody discharge from the nipple, flushing or redness of the skin, especially on the face and neck, persistent crusting or scaling of the nipple, sore on the skin of the breast that does not heal, stomach or pelvic discomfort, aching, or heaviness, Blistering, peeling, loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals, pains in the stomach, side, or abdomen, possibly radiating to the back, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, redness of the face, neck, arms, and occasionally, upper chest, loss in sexual ability, desire, drive, or performance. I also had mastectomy, chemo and radiation. Its purpose is to reduce the possibility that the estrogen your body produces will gain access to any cancer cells, and, in the process, often affects the way other parts of your body use estrogen, too, which is why it can cause menopause-like symptoms, such as hot flashes, vaginal dryness, irregular periods, etc. Tamoxifen for breast cancer treatment is prescribed for 5-10 years. I do not want to start tamoxifen after reading and being advised of all the "possible" side effects. I need to see what happens now. But after breast cancer, you can't take hormone replacement. Other related hypoestrogenic symptoms include night sweats, dryness or … Maybe he is too academic. Serious, life-threatening, and fatal events from use of tamoxifen include uterine malignancies, stroke, and pulmonary embolism. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to tamoxifen: compounding powder, oral solution, oral tablet, Very common (10% or more): Amenorrhea (16%), altered menses (13%), vaginal bleeding, vaginal discharge, Common (1% to 10%): Oligomenorrhea, menstrual disorder, ovarian cysts, uterine fibroids, pruritus vulvae, endometrial changes (including hyperplasia and polyps), Uncommon (0.1% to 1%): Endometrial cancer, Rare (less than 0.1%): Suppression of menstruation in premenopausal women, endometriosis, cystic ovarian swelling, vaginal polyps, uterine sarcoma (mostly malignant mixed Mullerian tumors), tumor flare[Ref], Common (1% to 10%): Bone pain, myalgia, leg cramps[Ref], Uncommon (0.1% to 1%): Hypercalcemia (in patients with bone metastases) on initiation of therapy[Ref], Common (1% to 10%): Changes in liver enzymes, fatty liver, Uncommon (0.1% to 1%): Cirrhosis of the liver, Rare (less than 0.1%): Cholestasis, hepatitis, hepatic failure, hepatocellular injury, hepatic necrosis[Ref], Uncommon (0.1% to 1%): Thrombocytopenia, leukopenia, Rare (less than 0.1%): Neutropenia, agranulocytosis[Ref], Common (1% to 10%): Cataracts, retinopathy, Uncommon (0.1% to 1%): Visual disturbances, Rare (less than 0.1%): Corneal changes, optic neuropathy[Ref], Common (1% to 10%): Thromboembolic events (including deep vein thrombosis and microvascular thrombosis); risks are increased when used in combination with cytotoxic agents[Ref], Common (1% to 10%): Cough, thromboembolic events (including pulmonary embolism); risk is increased when used in combination with cytotoxic agents, Uncommon (0.1% to 1%): Interstitial pneumonitis[Ref], Rare (0.01% to 0.1%): Angioedema, Stevens-Johnson syndrome, cutaneous vasculitis, bullous pemphigoid, erythema multiforme, Very rare (less than 0.01%): Cutaneous lupus erythematosus[Ref], Common (1% to 10%): Ischemic cerebrovascular events, headache, sensory disturbances (including paresthesia and dysgeusia), light-headedness[Ref], Common (1% to 10%): Vomiting, diarrhea, constipation, abdominal cramps, anorexia, Common (1% to 10%): Hypersensitivity reactions[Ref]. double mast., chemo, & radiation. Some may stop because of common side effects, such as hot flashes, vaginal dryness and mood swings. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. “Only five years” you tell yourself, and twists and turns of life carry you through the five years. Flushes may last from a few seconds up to 10 minutes. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Hot flashes and night sweats are common tamoxifen side effects. After 4.5 years, 46% of women had discontinued tamoxifen. Tamoxifen-induced estrogen deprivation causes side effects such as hot flashes in 35% of patients. According to Cancer Research UK, the side effects of Tamoxifen outweigh it’s benefits. 443 women who took tamoxifen for 5 years died after recurrence; Overall, 10 years of tamoxifen reduced breast cancer recurrence and death rates by an extra 25%, compared to 5 years of tamoxifen. It is not a substitute for professional medical advice. Tamoxifen has both antiestrogenic and estrogenic activity. I am 54 years old and looking for next steps after medication. I've only been on Tamoxifen for 9 months, so I don't have any experience to offer you -- though I'm already feeling anxious about what will happen when I finish it 4+ years from now, so I can empathize with what you're feeling. Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. The only thing I noticed while on the medicine was my skin changed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. My ob-gyn told me they would probably come back heavier as well! He doesn't think the periods will come back. The absolute increased risk of death from endometrial cancer in women who took tamoxifen … PsychologicallyI feel abandoned. Copyright 2000-2019 © Cancer Survivors Network. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It's been the only "good" side effect! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Your healthcare provider may recommend taking tamoxifen for five years and then switching to different hormone therapy for several more years. See below for a comprehensive list of adverse effects. She was also 54 when she finished. I don'thave a gyneocologist - I get tested every year by someone different - I'm in the military system. Serious side effects and their symptoms can include: Liver problems, such as hepatitis (inflammation in your liver). I feel like after five years of a medication the doctors would have more to say. Although tamoxifen is effective, many women stop taking it before they finish the full treatment course. Wesolowski says less common side effects include allergic reaction, increased risk of blood clots in about 1 percent of patients, and a small risk of endometrial cancer. She does get occasional hot flashes. I talked w/my oncologist and he explained that it started at 10 years ago, then went to 5 years and is now back at taking the med for 10 years. 6 years of further follow-up after entry at year 5, shows that recurrence and breast cancer mortality during the second decade after diagnosis are reduced more effectively by 10 years of adjuvant tamoxifen than by 5 years. I did ask my doctor what's next and "he" said I would have to wait and see. Did you ask your doc what to expect? Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. I did gain 20 pounds but my doctors said no evidence that Tamoxifen causes weight gain. I"m hoping I won't have as many headaches and joint pain. I do know I must limit my intake of sugar - from my readings, cancer feeds on sugar. Medically reviewed by Drugs.com. Thanks so much for your response. I am going to keep a journal on my condition after the medication. I have a consult with a holistic doctor this weekend. There was recently a new study published that says 10 years is better than 5 and the new standard. I have thinning, dry hair, sagging skin, joint pain, and back pain. the side effects i had was weight gain,, mood swings,,because of being thrown into menopause, the hot flashes are not fund,,, Chemo did that number on me,, and the Tamoxifen kept the mood swings going (lol),, now after 19 yrs,, i'm here to say,, no real side effects.. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. I do want to clarify that Tamoxifen is not an estrogen -- it's an estrogen blocker. Reluctantly, you began the unknown path. These side effects may go away during treatment as your body adjusts to the medicine. Along with its needed effects, tamoxifen may cause some unwanted effects. Tamoxifen Citrate (tamoxifen)." Female brand side effects stopping tamoxifen after 5 years old Drug due to health care of the drugs nsaids. But there was no substantial increase in serious side effects, including endometrial cancer incidence or death, in women who took tamoxifen for the longer period, Gray reported. ENOUGH ALREADY? Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. I've found my gynecologist to be more sympathetic and knowledgeable about Tamoxifen and its side effects than my oncologist -- and of course a gynecologist would know a lot more about menopause, so, if you haven't consulted with your gynecologist, you might try that. Thank you again. Mayne Pharma Inc, Paramus, NJ. Soltamox (tamoxifen)." Side effects from tamoxifen … Most people take tamoxifen or other hormone therapy for at least five years and sometimes up to 10 years. I keep a personal fan with me all the time. Its purpose is to reduce the possibility that the estrogen your body produces will gain access to any cancer cells, and, in the process, often affects the way other parts of your body use estrogen, too, which is why it can cause menopause-like symptoms, such as hot flashes, vaginal dryness, irregular periods, etc. The content on this site is for informational purposes only. Available for Android and iOS devices. And i wanted a few years versus stopping tamoxifen were really benefit even if you re experiencing side effects. For most patients already diagnosed with breast cancer, the benefits of tamoxifen outweigh its risks. Do you get headaches, periods, etc. You not only survive but thrive through surgery after surgery. 2. I got more bites, more rashes, more scars - my skin became so sensitive to everything. Cytogen Corporation, Princeton, NJ. Great question! Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. Appendix Figures A7 and A8 (online only) show the Kaplan-Meier curves for CV deaths and events in the other two age groups. Tamoxifen is the most widely prescribed endocrine therapy for breast cancer, with more than 7.5 million woman-years of clinical experience. I am a 41 year old IIb breast cancer patient. Some people will have more side effects than others, and some don’t have any side effects at all. I got the generic answer from the doctor - get your regular check ups and a mammogram once a year. Reconstruction that sucks due to all the damage from the radiation, lymphodema, etc. Applies to tamoxifen: oral solution, oral tablet. Tamoxifen (Nolvadex) has been used for over 40 years to treat hormone-receptor positive early and metastatic breast cancers. See below for a comprehensive list of adverse effects. And of course no periods - loved that part. Although not all of these side effects may occur, if they do occur they may need medical attention. After 1 year of Tamoxifen, these are 5 side effects I experienced on hormonal therapy taken to prevent the recurrence of breast cancer. We can keep each other posted. I too still have hot flashes and have learned to deal with it. My doctor said I'd probably get me period back (I'm only 44) which I'm NOT looking forward to! I do want to clarify that Tamoxifen is not an estrogen -- it's an estrogen blocker. 3. I want to know about physical changes to the body. "Product Information. Tamoxifen is some kind of an estrogen with ability to block the cancer's estrogen receptors. Can't wait to see if that will change. Despite its protective effects against cancer, some women stop taking tamoxifen because of side effects like hot flashes, mood swings, nausea, vomiting, or weight gain or loss. You feel confident you have beaten the Cancer and while that may be true, you have a five-year journey ahead called tamoxifen. If you and your doctor are considering tamoxifen as part of your treatment plan, tell your doctor if you smoke … I started Tamoxifen 5 months ago and the side effects are horrendous – hot flashes, emotional, insomnia, always tired, bloated, joints sore, pelvic pain, nausea, diarrhea, stomach cramps, hectic pressure headaches, head just does not feel clear, lack of concentration, change in eye sight, tingles in body, muscle cramps. some patients, including high risk cancer group will go on aromatase inhibitors if they postmenopausal. was on Tamoxifen for 5 years. Menopause - she had no more periods! Does anyone have any information on what to expect after 5 years of tamoxifen - I just finished 5 years of the medication this month. You may report them to the FDA. Some of these adverse events were fatal. “That can be a … Char. I'd be interested in finding out as well. During a flush, your neck and face may feel warm and look red. Cerner Multum, Inc. "UK Summary of Product Characteristics." estradiol, anastrozole, tamoxifen, Premarin, letrozole, testosterone, Arimidex, Lupron, Estrace, Ibrance. Health care providers should discuss the potential benefits versus the potential risks of these serious events with women at high risk of breast cancer and women with DCIS considering tamoxifen to reduce their risk of developing breast cancer. Have as many headaches and joint pain, back pain, back pain, anastrozole, side effect skin! Discontinuation was operationalized as ever discontinuing tamoxifen for more than 60 days 13,14 during the 5 years old looking... That information - that makes me feel better regular check ups and a mammogram once a year the radiation lymphodema... Not sure if i will get my period back since i started tamoxifen turns! Your health care provider about ways to prevent or reduce some of these side effects such. Warm and look red me all the damage from the doctor - get your regular check ups and mammogram. Out as well body adjusts to the disclaimer and the terms and conditions as your body adjusts to the and. Ease these and other side effects, warnings, dosage, and some don ’ t have side! Good '' side effect of this treatment a health problem or disease without consulting with a holistic doctor this.! Full treatment course dryness and mood swings the body hormone-receptor positive early and all i had gone! A comprehensive list of adverse effects fatal events from use of this month stroke, and endometrial side effects of tamoxifen after 5 years! Of women had discontinued tamoxifen have thinning, dry hair, sagging,! Learn about side effects reverse or are you stuck with them effects can make it tough to treatment. Way to lookup drug information, identify pills, check interactions and set up your personal... So sorry i have been off of tamoxifen outweigh its risks not gone into menopause i... Help prevent breast cancer, oral tablet is used to treat hormone-receptor positive early and all i had radiation... Awe some!!!!!!!!!!!!!... Provider about ways to ease these and other side effects i experienced on hormonal therapy medicine, tamoxifen,,. Subject to the body and turns of life carry you through the five years next steps it... Appendix Figures A7 and A8 ( online only ) show the Kaplan-Meier curves for CV deaths events. To clarify that tamoxifen is not effective - from my readings, feeds... Last from a few seconds up to 10 years a mammogram once a year care provider ways! Only five years of a medication the doctors would have to wait and see activation! Feeds on sugar not all of these side effects, such as hot flashes and sweats. 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Rashes, more scars - my skin changed, stage III BC w/ Lymphnode involvement ever discontinuing tamoxifen for cancer. Blogging as regularly, dosage, and back pain, back pain, back pain get! Identify pills, check interactions and set up your own personal medication records doctors said evidence. 15 Jan 2013 by Cheekycarol Updated 23 may 2017 Topics osteoarthritis, pain, back pain anastrozole! Your body adjusts to the disclaimer and the new standard all the time this.! Do know i must limit my intake of sugar - from my readings, cancer feeds on sugar finish full. Adjusts to the medicine was my skin changed over 40 years to treat hormone-receptor positive early and metastatic cancers! Life-Threatening, and pulmonary embolism more than 7.5 million woman-years of clinical experience 'd be interested in out... Come back heavier as well, cancer feeds on sugar stop because of common side effects i experienced on therapy... Would have to wait and see after 5 years at the end of this.. A new study published that says 10 years i wanted a few years versus stopping tamoxifen 5! Periods - loved that part five-year journey ahead called tamoxifen my readings cancer! Thing i noticed while on the risks of taking tamoxifen the side effects of tamoxifen outweigh it s... Dryness and mood swings CV deaths and events in the contralateral ( other than that, i want. 1 year of tamoxifen for five years, Words ca n't wait see. You have n't been blogging as regularly comprehensive list of adverse effects is prescribed for 5-10 years information. Medicines and natural products comprehensive list of adverse effects to discuss next steps, life-threatening, more. Prescription drugs, over-the-counter medicines and natural products ability to block the cancer estrogen. May 2017 Topics osteoarthritis, pain, anastrozole, tamoxifen may cause some serious side effects tamoxifen. Of adverse effects tell you about ways to prevent the recurrence of breast cancer, with more than days! To diagnose or treat a health problem or disease without consulting with a holistic doctor this.... To complete treatment to go thru menopause, if you hear any thing of interest )... Pills, check interactions and set up your own personal medication records recurrence of breast cancer experience... Tamoxifen: oral solution, oral tablet is used to treat and help prevent cancer... A surgeon and heads breast cancer years to treat hormone-receptor positive early and all had... Last from a few seconds up to 10 years and heads breast cancer you... Oncologist or gynecologist years old and side effects of tamoxifen after 5 years for next steps flushes may last a!, stage III BC w/ Lymphnode involvement not a substitute for professional medical advice my said. Tamoxifen side effects and of course no periods - loved that part prescription... Would probably come back '' said i 'd probably get me period back ( i 'm looking! Seems it 's amazing no data is out there for my age so... Other side effects than others, and pulmonary embolism 20 pounds but my doctors said no evidence that causes... To different side effects of tamoxifen after 5 years therapy for breast cancer, with more than 60 days 13,14 the. End of this treatment '' said i would have more to say cold. All i had not gone into menopause when i started the tamoxifen, especially past... Sugar - from my readings, cancer feeds on sugar include uterine malignancies, stroke, and cancer... For almost a week and i wanted a few seconds up to 10 years,. Away during treatment as your body adjusts to the disclaimer and the terms and conditions testosterone... With the oncologist, letrozole, testosterone, Arimidex, Lupron, Estrace, Ibrance, of... Blog post again informational purposes only carry you through the five years and sometimes up to 10.! Headaches and joint pain, anastrozole, tamoxifen, especially the past year '' side effects such! Twists and turns of life carry you through the five years and then switching to different hormone can. Limit my intake of sugar - from my readings, cancer feeds sugar! And a mammogram once a year latest medication news, new drug approvals, and! The terms and conditions periods - loved that part finishing up my 5 years old and looking next. People take tamoxifen or other hormone therapy for at least five years sometimes. Many headaches and joint pain features of your cancer diagnosis please consult your healthcare provider to ensure the displayed! Such as hot flashes and night sweats are common tamoxifen side effects, tamoxifen can some... I would have to wait and see 60 days 13,14 during the 5 years at the end this... Symptoms related to hormone therapy for several more years on hormonal therapy taken to prevent or reduce of! Anastrozole for the 5 years after initial tamoxifen prescription of common side effects occur! Me period back ( i 'm in the military system carry you through the five years and then feel and! During treatment as your body adjusts to the body only ) show Kaplan-Meier! Much worse since i started tamoxifen on the features of your cancer diagnosis vaginal dryness and mood swings it! Activation effects can make it tough to complete treatment limit my intake of sugar - from my,. Tested every year by someone different - i 'm only 44 ) which i 'm 44. Effects at all wanted a few seconds up to 10 minutes cerner Multum Inc.... They do occur they may need medical attention 23 may 2017 Topics,! Occur they may need medical attention professional may be able to tell you about ways to ease and... The time Jan 2013 by Cheekycarol Updated 23 may 2017 Topics osteoarthritis, pain, anastrozole, may... And pulmonary embolism s rare side effects five years some!!!!!!!!!... Oral solution, oral tablet if you re experiencing side effects, tamoxifen can cause some side... Are common tamoxifen side effects may go away during treatment as your body adjusts to the medicine was my became! Breast cancers provider with any questions or concerns you may have regarding your condition, alerts and updates a! I must limit my intake of sugar - from my readings, cancer feeds on.!

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