I know it's scary but I had an allergic reaction to letrozole and had to stop taking all my medication including my in gales and lanzaporole and then slowly introduced them back but not the letrozole I have now been put on exemestane and yes still have joint pain but if it's to bad I take paracetamol. #1 is a problem with my hands, unable to make fists or grip a knife to cut meat, hands feeling swollen every morning. However, they may be more problematic for some women. If bleeding continues for more than a few days, tell your doctor or nurse. It’s sometimes given before surgery to shrink a larger breast cancer. Always inform your doctor or nurse of the side effects you experience. If your eating problems do not improve, talk to your doctor or nurse. We’d love to keep in touch about news, events and how you can get involved. I completed the full five years as prescribed. You won’t need to stop taking it gradually. Natural fabrics such as cotton may be most comfortable. This will depend on your individual circumstances, but letrozole is usually taken for five to ten years. If you are taking other drugs, you may have certain side effects that are not listed here. If this is the case, make sure you talk to your cancer doctor or nurse. HOT FLASHES AND SWEATING. These include complementary therapies and herbal remedies. • Some people find it helpful by avoiding alcohol, spicy food, caffeine intake (coffee, tea, colas, chocolate). Breast Cancer Now is a company limited by guarantee registered in England (9347608) and a charity registered in England and Wales (1160558), Scotland (SC045584) and Isle of Man (1200). Most side effects settle down a few months after taking letrozole or can be controlled or managed. It is normally taken over a number of years. Your ankles and feel may swell up because of the build-up of fluid. If you're taking adjuvant hormonal therapy medicine now, stick with it as prescribed. Find out more about the side effects of letrozole. Letrozole is usually given after surgery to reduce the risk of breast cancer coming back or spreading. Many types of breast cancer depend on the hormone estrogen to grow. They can normally suggest ways to improve the side effects. Or they may have difficulty concentrating or may feel anxious or have trouble sleeping. Let your doctor or nurse know if this happens. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones. It can help to lower your intake of nicotine, alcohol, and hot beverages containing caffeine such as tea and coffee. Tell all of your health care providers that you take letrozole. What happens when you stop taking Letrozole? I had an estrogen cancer and I have been on letrozole for a year. Talk to your specialist, pharmacist or GP about any complementary therapies, herbal remedies or supplements you want to use before you start using them. Although not all of these side effects may occur, if they do occur they may need medical attention. If your cancer is hormone receptor negative, then letrozole will not be of any benefit. "If the side effects from letrozole are intolerable, benefits are maintained by switching to tamoxifen rather that stopping hormonal therapy altogether." Letrozole can also be used to treat breast cancer that has come back (recurrence). Some people worry about stopping their treatment, but there’s evidence that letrozole continues to reduce the risk of breast cancer coming back for many years after you stop taking it. I just read this question and the feedback because I just decided yesterday to stop taking the Letrozole that I've been taking for 7 months. 3. Who it’s suitable for If you’re thinking about stopping taking letrozole for any reason, talk to your specialist first. Nausea is usually mild, but tell your doctor or nurse if this happens. Try to pace yourself until this improves. How does letrozole work? Letrozole is a drug used to treat breast cancer in women who have gone through the menopause. The pills are taken at the same time each day, either in the morning or at night. I finished taking 5 years of first Tamoxifen then Letrozole, 2.5 years each. Given that one in three patients taking tamoxifen or aromatase inhibitors eventually develop resistance, the researchers … Letrozole is taken as a tablet once a day, with or without food. Doctors sometimes prescribe it before or after another type of hormone therapy. What are some things I need to know or do while I take Letrozole? However, not taking the drug for the recommended time may increase the risk of your breast cancer coming back. It can cause mild withdrawal symptoms that can include the following:-Dizziness-Nausea-Headache-Sweating-Depression-Insomnia. Some women notice that their hair thins out while they are taking letrozole. Stopping Letrozole? These are known as oestrogen receptor positive or ER+ breast cancers. You should not use letrozole if you are allergic to it. Non-hormonal creams and gels or lubricants can help reduce vaginal dryness and discomfort during sex. If this happens, your doctor may give you medicine to lower the cholesterol and fat in the blood. If you have to go to the hospital for whatever reason other than cancer, always tell the doctors and nurses that you are taking letrozole. Men with breast cancer may be given letrozole, although another drug called tamoxifen is more commonly used. Posted: December 2, 2011; If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. #2 is possibly just the inability to bounce … Hormone therapies interfere with the way hormones are made or formed in the body. If you do not have much of an appetite, try eating small meals on a regular schedule and often. Withdrawal: Consult your gynecologist for a better way to discontinue your hormones. Explain that you are taking hormone therapy and that no one should start or stop it without taking to your cancer specialist in the first place. These drugs are often prescribed after breast cancer surgery, chemotherapy or radiation therapy to help prevent a recurrence of the disease. Your treatment team will tell you when to stop taking letrozole. 5. Talk to your nurse or doctor if you experience these changes so that they can give you support and. Use effective birth control if you are not past menopause. Letrozole is taken once a day in tablet form. This is why, this product can be stopped abruptly. For these reasons, before you start taking letrozole it is important that your doctor knows: If you have not yet gone through the menopause, or if there is a possibility you could be pregnant. Do not start, stop, or change the dose of any drug without checking with your doctor. Taking short walks regularly will help you feel less tired. Some people worry about stopping their treatment, but there’s evidence that letrozole continues to reduce the risk of breast cancer coming back for many years after you stop taking it. Aromatase inhibitors may cause muscle and joint aches and pains. Get a new prescription before the one you have runs out, and keep track of holidays, when pharmacies may be closed. This usually improves as your body adjusts to letrozole. • If night sweats interfere with sleep, try taking your letrozole in the morning. If you have a loss of bone density, or 'brittle bones' - a condition known as osteoporosis. Eating healthy meals and becoming more physically active can help you maintain a healthy weight. This includes your doctors, nurses, pharmacists, and dentists. Your doctor may check your cholesterol levels with a blood test. How long will I have to take it? These drugs, which include Arimidex (anastrozole), Aromasin (exemestane), and Femara (letrozole), are usually given to postmenopausal women. You may gain weight when taking hormone therapy. Return the remaining pills to the hospital if the treatment is discontinued. Keep the pills in their original packaging at room temperature. Your nurse will monitor it regularly during treatment. Here, we explain the most common side effects of letrozole. Talk to your specialist or advice line before you stop taking a cancer drug. It is also used to treat early breast cancer in women who have experienced menopause and who have already been treated with a medication called tamoxifen (Nolvadex) for 5 years. Now 2 months later, without letrozole I am feeling much better. Tell your doctor if this does not get better. What is letrozole? It can help to lower your intake of nicotine, alcohol, and hot beverages containing caffeine such as tea and coffee. Some people worry about stopping their treatment, but there’s evidence that exemestane continues to reduce the risk of breast cancer coming back for many years after you stop taking it. They can prescribe drugs to help control them and can also give you advice on managing side effects. Letrozole belongs to a group of drugs called aromatase inhibitors. It’s best to take it at the same time every day. If this happens, it is likely to occur in the first weeks of treatment or when changing from another hormone therapy to letrozole. After menopause, estrogen is no longer made in the ovaries. In the study, 13% of women stopped taking the drugs due to side effects such as joint and muscle pain. I have another appt booked at the oncology clinic in early December so I will talk further about it with whomever I see at that time. You may have bleeding when you start this treatment, or if you change to it from another treatment. If you forget to take a pill, take one as soon as you remember. Taking letrozole with other drugs. If you miss a dose, you don’t need to take an extra dose the next day. It is very important that you do not stop taking letrozole without telling your doctor, as this may affect the success of the treatment. If you notice any changes in your heart rate, tell your doctor immediately. It can also take several weeks or months to reverse bad sleeping habits caused by Arimidex. Keep using birth control for at least 3 weeks after your last dose of letrozole. 54 years experience Neurosurgery. Your hair will thicken after the treatment ends. When you start to take letrozole, you may feel tired, drowsy, or feel like you have no energy. You can use non-hormonal creams, gels or lubricants to help with vaginal dryness and any discomfort during sex. letrozole is for use only in women who can no longer get pregnant. 4. Hospital Universitario Fundación Jiménez Díaz, Strategic plan of the Oncohealth Institute. Why Buy Letrozole? Do not stop taking letrozole unless your doctor instructs you to. Bone fracture; breast pain; chest pain Instead it's made in the fatty tissues of the body. This medicine may increase the amount of cholesterol and fat in the blood. Letrozole is used treat early breast cancer in women who have experienced menopause (change of life; end of monthly menstrual periods) and who have had other treatments, such as radiation or surgery to remove the tumor. How long after being disease-free from breast cancer is it safe to stop letrozole (Femara)? However, not taking the drug for the recommended time may increase the risk of your breast cancer coming back. This is important to ensure that it is working as well as possible. They can give you drugs to help. Dress in layers so you can remove clothing if you need to. How it’s taken  Healthy eating and staying physically active will help if you have worries about your weight. It should go away when the drug is out of your system which shouldn't take longer than 4 days to a week. Occasionally, letrozole may be used as the first treatment for breast cancer, for example when surgery isn’t appropriate or needs to be delayed. Let your health professionals know if you have any of these symptoms. Always tell your doctor or nurse about any change to your eyesight. Research has shown that about 25% of women who are prescribed hormonal therapy to reduce the risk of recurrence after surgery either don’t start taking the medicine or stop taking it early, in many cases because of side effects. I have had several minor side effects, but 2 side effects that I deem as too important to continue taking the daily pill. They should be stored away from heat and direct sunlight. This medicine may make you dizzy, drowsy, or tired than they are normally. His feeling was that as there is no evidence that continuing Letrozole after 5 years is beneficial, I should stop taking it after December. Before taking this medicine. Talk to your doctor if side effects from Arimidex are persisting despite stopping it. Do not use if you are pregnant. Letrozole is a product that generally do not need to be stopped taking it gradually. Do not stop taking letrozole unless your doctor instructs you to. It can also be given to treat breast cancer that has spread to another part of the body (secondary breast cancer), when it’s often given alongside another drug. Thanks for your thoughts, I think the reason the oncologist is asking me to stop taking Letrozole is to see if it is causing this painfully condition and until it's out of my system he does not know whether to change to another Al. We have … There are certain important things to remember when taking the tablets. Your doctor will determine your dose and how long you will be taking Letrozole. Tell your doctor if you are taking any other medication. Sometimes it may be possible to change to another hormone drug. Posts: 446 Joined: Jan 2008 Apr 10, 2009 - 5:23 pm. You may develop a mild skin rash. Letrozole can harm an unborn baby. ohilly. If your vaginal bleeding continues for more than a few days, tell your doctor or nurse. These act as chemical messengers and help control the activity of cells and organs. This is there any withdrawal after stop taking letrozole page on EmpowHER Women's Health works best with javascript enabled in your browser. Letrozole works by reducing the amount of oestrogen made in the body. Your nurse can give you further advice on this. Tell your doctor or nurse if you have ever had problems with blood pressure. It is very important that you contact your doctor immediately if you develop a sever rash. However, some side effects, such as high cholesterol, lymphedema, osteoporosis, and vaginal dryness may persist despite discontinuation of Arimidex. Letrozole is also used to control breast cancer that has spread to other parts of the body (secondary breast cancer). Learn about side effects, warnings, dosage, and more. Letrozole is a hormone therapy drug. Dr. Edward Smith answered. If hot flashes are troublesome: • Try taking your letrozole at bedtime. just been taken off letrozole after one year and four years on tamoxifin It looks like you have javascript turned off. Let your doctor or nurse know if this happens. These are common and tend to be mild, though they can vary. The half life of the drug is 2 days so it should be out of your system within 4 days. Do not stop: Letrozole ... Hi, i stopped taking femara (letrozole) two weeks ago - cold turkey and have been having a lot of headaches, dizziness, nausea, muscle and joint pains, tiredness? When letrozole is given Let your doctor know if you have pain or discomfort when urinating, if you urinate more frequently than normal, or if your urine is cloudy or foul-smelling. Always let your dentist know that you are taking letrozole. However, women who are prescribed this product for breast cancer shouldn’t stop taking it unless their doctors recommends to do so. Letrozole can interact with other drugs. Letrozole is a drug called an aromatase inhibitor. Along with its needed effects, letrozole may cause some unwanted effects. This type of breast is called estrogen receptor-positive (ER-positive) breast cancer. They may also recommend that you take calcium and vitamin D supplements. 7. Side effects of letrozole However, not taking the drug for the recommended time may increase the risk of your breast cancer coming back. 2. You will normally have a bone density scan to check on the healthiness of your bones before and during the treatment. There are a number of other brands of letrozole, all of which contain the same dose of the drug. If you’re taking any other prescribed or over-the-counter medicines, check with your treatment team or pharmacist if you can take these with letrozole. 8. Even though their ovaries have stopped producing estrogen, it is still produced by the aromatase enzyme found in other tissues. Except when it is almost time for your next dose, do not take a double dose. This happens when an enzyme called aromatase changes other hormones into estrogen. You should take the right dose, not more or less. If you’re taking letrozole to treat breast cancer that has come back or spread to another part of the body, you’ll usually take it for as long as it’s keeping the cancer under control. The study also looked at how stopping hormonal therapy affected the women's risk of dying. 6. There is hope after this med! Hormones are substances produced naturally in the body. In this section, you can read about why it's so important to stick to your treatment plan and ways to handle possible difficulties in following radiation, chemotherapy, and hormonal therapy regimens. Letrozole is also used in women who have experienced menopause as a first treatment of breast … I hope this … Some women find that their appetite increases. Tell your doctor or nurse if this is a problem. Taking letrozole for a number of years increases the risk of bone thinning (osteoporosis). Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. It is important to strike the correct balance between getting enough rest and staying physically active. Letrozole can also cause indigestion or abdominal pain. It is used to treat breast cancer in women who have gone through menopause. You may have pain or stiffness in the joints, or sometimes in your muscles. It blocks this process and reduces the amount of estrogen in the body. A study reports on the results of several different studies looking at how often side effects made women stop taking hormonal therapy. Yes this is a common reaction when you stop taking Femara. Always take the pills exactly as your nurse or pharmacist has told you. Physical activity and maintaining a healthy weight can help reduce joint pain and keep joints flexible. Letrozole may cause dizziness. Sometimes letrozole is given alongside a drug called goserelin (Zoladex) to women who haven’t yet been through the menopause. Letrozole is suitable for women who have been through the menopause and whose breast cancer is oestrogen receptor positive. Hormone therapy is a very common treatment for secondary breast cancer and many people take it for a long time. You may experience some of the side effects mentioned here, though it is rare for a patient to have all of them. Tamoxifen may cause hot flashes. If you have any questions about this, talk to your doctor. Hot flashes and sweating can subside after the first few months. Keep them safe and out of the reach of children. If letrozole stops working, your specialist may prescribe another hormone drug. This treatment can cause vaginal changes. I stopped taking it a month ago cause My hips and shoulders felt like they were coming out my sockets. You may also hear it called Femara, which is its best-known brand name. Normally, this can be easily controlled with drugs. I hope this helps. You can buy these from a chemist, or your doctor can prescribe them. Sometimes, doctors give letrozole before surgery to try to reduce the size of the cancer and avoid having to perform a mastectomy (removal of the breast). Letrozole is used after surgery and other treatments to reduce the risk of breast cancer returning. Tell your doctor if you notice this or any other type of swelling. Let your doctor or nurse know if you have headaches. This may increase the risk of bone fractures. Unlike the drug clomiphene, which was prescribed in the past, letrozole doesn’t cause mood changes or affect the endometrial lining or cervical mucus. They can prescribe painkillers and give you advice. These are common and tend to be mild, though they can vary. Sometimes, women have irritated eyes or blurred vision when taking letrozole. One more time/what happens when you stop AIs. I had bad joint pain in my knees for the full time and hot flashes as well as some foggy mental functioning. Sometimes it may … In rare cases, women may have vaginal bleeding. Do not take other drugs containing oestrogen, such as hormone replacement therapy (HRT), while you’re taking letrozole as this may interfere with its effectiveness. Tell your doctor if your hot flashes become bothersome. Some people start taking letrozole after a few years of taking the hormone therapy drug tamoxifen. Three months ago I started with bone and joint pain. Some women may discover that they feel down when taking letrozole. when you first start taking letrozole. If you accidentally take too much letrozole (Femara), contact a doctor or hospital straight away.You might need medical treatment. Less pain in the knees but still getting better gradually. If you have any problems with the way your liver works, or any problems with the way your kidneys work. This is normally mild. Arimidex (anastrozole) is a brand-name prescription drug that’s used for certain types of breast cancer. Some breast cancers are stimulated to grow by the hormone oestrogen. It the side effects are very bothersome and are unmanageable, your oncologist may suggest you start on a different hormone therapy. No one responded to my post about this, so I'll try again: I've only been taking Femara, but I'm already wondering: so what happens in 5 or 10 years (new research shows we might have to be on this stuff longer) when we stop taking our aromatase inhibitors? If you’re having chemotherapy or radiotherapy, your specialist will tell you when it’s best to start letrozole. Hot flashes and sweating can subside after the first few months. Where to Purchase Femara (Letrozole)? The level of drug in your body will remain high enough from the day before. Drink lots of fluids if you think you may have an infection. You won’t need to stop taking it gradually. To hear from us, enter your email address below. If you have any worries or questions about taking or stopping letrozole, you can call us free on 0808 800 6000 to talk through your concerns. You should not stop taking Letrozole without discussing with your physician. The amount of Letrozole that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition being treated. Low doses of certain antidepressants can help reduce hot flashes. 1. Casper says that about 1 percent of people who take letrozole get leg cramps and headaches, but the good news is that these symptoms go away once you stop taking the pills. If you’re thinking about stopping taking letrozole for any reason, talk to your specialist first. This includes medications that can be purchased in a store or pharmacy. If you feel drowsy, don't drive or operate heavy machinery. Registered Office: Fifth Floor, Ibex House, 42-47 Minories, London EC3N 1DY. Taking regular walks, eating a healthy diet, not smoking, and following guidelines for drinking alcohol will also help strengthen your bones. If you have pain or pressure in your chest or feel out of breath at any time during or after treatment, let your doctor know immediately. Both tamoxifen and aromatase inhibitors can cause side effects. If you are at risk of developing osteoporosis, your doctor may prescribe drugs called bisphosphonate to protect your bones. 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